If you're looking for anime similar to VALIS: Shinsekai Pygmalion, you might like these titles.
A psychopathic killer known as Egg Man has been caught, incarcerated and is awaiting his death sentence. Karen, a beautiful and brave police woman, is assigned to the "Egg Man" case to find the whereabouts of a missing dead body. Egg Man meets his cellmate, Prisoner 205. Who is Prisoner 205? Is Prisoner 205 another in-mate awaiting his death sentence as well or an android utilized by the police to collect information about him and his knowledge of the corpse? Who is really manipulating whom?
A man posts his dissatisfaction with everyday life on social media. He gets lost in GeGeGe Forest.
On a cold planet of ice and snow, mysterious creatures suddenly have appeared from the dark underground and have begun to attack the inhabitants. Can humanity survive the terror lurking beyond the horizon?
In a dark dystopic future, humankind is controlled by Dorothy, a sentient supercomputer who believes she is god. To help do her bidding, she created beings known as Galerians -- humans with supernatural and psychokinetic abilities that rival no other. Enter Rion, a young man who possesses the skills of the Galerians, and unwillingly holds the key to Dorothy's destruction within his mind. As enemies search to destroy him, Rion must race against the clock to find his long lost sister and save humanity, before Dorothy and the Galerians can destroy it...
A demon has emerged deep beneath Tokyo. The governor of Tokyo and his escort unit go to inspect, but are trapped underground. Surrounded by darkness, with nowhere to go, people lose their reason and become consumed by the demon.
A man approaches a sinister-looking house, not knowing how he got there or where he is. He has arrived at the Gregory Horror House, a place where strange creatures and mysterious specters float the halls and inhabit the rooms. From the teetering, toothy Judgment Boy who roams the corridors to a sexy and bloodthirsty reptilian nurse, from a gun slinging compadre and beyond, there are plenty of bizarre tenants of Gregory Horror House; but what's really going on, and why do people find their way to this place?
Rin’s new apartment building is a far cry from the sunny, idyllic photos from the rental brochure. And instead of offering sanctuary from a dangerous world outside, it oozes decay and dread. Residents exhibit unsettling, peculiar qualities and grotesque eruptions. Sinister forces seem to lie around every corner, and if Rin wants to survive, she will have to discover the terrifying truth — one she has kept buried within…