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There exists an organization called B-Kikan made up of Jittoku, Nemu, and their boss. They help fight against Insects, parasitic organisms made by the government that feed on human bodies for nutrients.
Taking place on the planet Vekta, where the ISA and Helghast have been fighting a very long war. The ISA mercenary Ross and his partner Huey meet Chajans, the sole survivor of an ISA platoon that was wiped out by the Helghast. When Ross hears of the destruction of Chajans' platoon, he decides to carry out the platoon's mission of protecting a target himself, in order to get a rewa