It is said that there are four types of people in the world; those that know and know that they know, those that know and don't know that they know, those don't know and know that they don't know and those that don't know and don't know that they don't know. It's clear right from the start of this series that the main character is, in the language of the show, a pervert with an insatiable fetish for women's undergarments. And if that truth is enough to turn your head in disinterest or disgust, this is probably an anime for you to skip. But while the viewer is fully aware of Aito's proclivities, there's something a bit different about him than can be found in many other stories with characters like him. He is oblivious to his tendencies and how they effect those around him. Stated differently, he doesn't know and doesn't seem to know that he doesn't know. For those not ready to dismiss this story by way of first impressions, there are some good laughs and endearing moments to enjoy.
As Mangaka-san to Assistant-san to develops and Aito becomes surrounded by cute female characters, the viewer wonders why and how each tolerates his behavior. The series is composed of 12 episodes, 13 minutes each, and most of the episodes themselves are composed of 3 mini-stories. Knowing this, the viewer also wonders if it's possible to answer those questions in such a short form. One of the show's strengths is its pace. The comedic timing is aided by it's quick speed. Another strength is that though there isn't much time to tell the whole story given the format, somehow almost all of the character's backstories and motivations are revealed by the end of the series. And the best stories tend to feature characters that start at one place and transform over time. Almost all of the characters in this story do grow in one way or another which is nice to see.
Mangaka-san to Assistant-san to is good for what it is; a light, over-the-top comedy about an oblivious male manga artist obsessed with panties and his team of female assistants who stand by him despite his flaws told in a rapid fashion that for those who don't object to the subject matter may take you by surprise. There is more to almost every character than one would presume by way of first impressions and for those who stick with it, the story has a pleasant charm. For those willing to give the show a try, set upon watching the first 6 episodes for a better impression of the series. If you (still) hate it by then, let it go. If you appreciate it it for what it is, you'll be satisfied by how the show wraps up.