If you're looking for manga similar to Xenosaga: Super Comic Gekijou, you might like these titles.
2034, a time when the development of AI advanced greatly and the appearance of the humanoid “Totomo” has been widely accepted. Tamotsu, an ordinary office worker, loses both his daughter and has half his body replaced with mechanical parts due to an accident. While trying to live earnestly with his wife, his body begins to malfunction…
After a terrible accident occurred at the lab, Professor Komyouji vanished - and with him, the hopes for completing his most recent creation: Jiro, a robot with a malfunctioning conscience circuit. With no memory of who he is or what is his purpose, Jiro is mentally lost; his saving grace is the Professor's daughter, Mitsuko, who - though afraid of Jiro - pledges to help him either repair his circuit or destroy him if his emotions become out of control. Unfortunately for Jiro, there is a far more sinister danger at hand: Professor Gill and the evil organization Dark are sending countless robots to destroy him, forcing Jiro to transform into his full cyborg self, Kikaider. With the help of Mitsuko, Jiro must ward off the forces of Dark while trying to discover what it means to be human...
The life of a cyborg, programmed to protect his overprotective older brother and ordered to conceal his identity from his classmates.
Due to a request, the genius Dr. Sumiko developed an [AI boyfriend]. Sumiko is pleased with her success, but the AI boyfriend who started will recognize her as [girlfriend]...!? Initially, Sumiko rejected the AI boyfriend. However, being subject to his constant love gradually leads her to acknowledge him...
Anti-social Kokuyo seems to always wind up in the hospital due to overwork from his busy writing career. Unable to bear Kokuyo's lifestyle problems any longer, his friend Seiki gives him a "replicant," a male android named Shiro, who can monitor his health and do his daily chores...among other things. At first, Kokuyo can't hide his irritation toward the bumbling Shiro, but eventually his feelings begin to change. Will Shiro's puppy-like devotion and dogged perseverance win over Kokuyo's heart in the end?