A list of manga that have one or more protagonists who are transgender.
A list of manga that has one or more LGBTQ+ main characters. Manga that are BL or GL are not included.
These manga feature LGBT themes that focus on gender and gender identity, including trans-related topics, rather than the sexuality side of the tag.
A comprehensive list of manga that feature transgender characters and themes. I'm still evaluating some other manga, but if there are any I've left out, or if you find an error, PLEASE let me know in the comments. ...