If you're looking for manga similar to Saint Young Men, you might like these titles.
Nozomu Itoshiki is a high school teacher who views everything in life in the most negative way possible. Even his name reflects his personality: if the Japanese characters are written horizontally, they spell out 'despair.' One day during one of Nozomu's many suicide attempts an incredibly optimistic young girl named Kafka Fura rushes to save him from hanging on a sakura tree. Nozumu later finds out that Kafka is a student in his new class! In fact Nozomu's new class seems to be made up entirely of strange, troubled individuals who constantly foil his attempts to end his life.
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Saint Young Men and Sayonara Zetsubou Sensei are parody series that mock modern Japanese society and pretty much everything else. Both are peppered with pop culture (especially references to other manga/anime).
On the surreal premise that women's mouths take the often weird shape of their partner's penis, Yoriko starts an investigation to discover with whom her boyfriend is cheating...
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Genesis (from Kasutoro Shiki) and Saint Oniisan are two irreverent gag manga about religion and god(s).
Prove yourself worthy with this Soviet Russia fetish manga! Historical figures such as Lenin, Stalin, and even Gorbachev all play an important role in this absurd delusional fantasy about the greatest Communist nation to exist. Cheer as the ghost of Stalin helps a young foreign minister win back the Kuril Islands! Gasp in horror as Gorbachev is turned into a Neo-Nazi cyborg, throwing Russia into turmoil with the power of Glasnost! Marvel at the wonder that is Soviet Land, now open in Japan! They say it's ridiculous, and violent, but it's good for you and for the motherland!
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A bit of a stretch, but if you enjoyed one of these irreverent gag manga where nothing is off-limits, you may enjoy the other. Saint Oniisan mainly pokes fun of religion, while Dance! Kremlin Palace mercilessly mocks anything and everything Russian (and is much more explicit).
The time is several millennia ago; the place is India. Droughts and famine plague the country, and its people are forced into a strict caste system that rewards only the elite cream of the crop. Across the land animals and Brahmin alike rejoice, for the blessed child with a birthright to become a god is about to be born. His name is Siddhartha Gautama, later to be known as the Buddha. However, Siddhartha's life will not be an easy one. He will experience love and loss, learn about the value of life and influence the lives of many, including Tatta and Pariah, Bandaka the bandit and countless others.
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Both series feature the historical Buddha as a main character. One is told from a historical point of view, the other is set in a comedic, modern setting.
Japanese Hell consists of 272 subdivisions, and the demon Hozuki is tasked with making sure they all run smoothly. Calm and level-headed, he efficiently navigates Hell's internal affairs while his boss, the Great King Enma, is busy judging the dead. Although Hozuki has a soft spot for cute animals and is known for his love of gardening Goldfish Flowers, he's certainly no pushover. This demonic bureaucrat has a mile-wide sadistic streak that keeps his subordinates and even King Enma himself in check. Is Hozuki's iron will - and iron club - enough to keep the afterlife running smoothly?
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Both of these series are comedies featuring various characters from various religions and folklore. One stars Jesus and the Buddha taking a break from Heaven as roommates in Japan, the other involves workers employed under King Enma in Japanese Hell.
Two aliens are sent to Earth to scout for resources: that's how their adventures in Tokyo begins.
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Both share the theme of two bachelors living as roommates sharing comedic slice of life adventure. One series just happens to be aliens and the other Deities.
Creating the world was a big job, but God finds that actually running it is a lot more work. Dealing with heaven, earth, and everything in between can make it hard for him to kick back and have a drink. Fortunately, he has Jesus and his right-hand man Gabe to keep things going in heaven and deal with the fallout of their Lord's many mishaps. Meanwhile, Lucifer and his assistant Ebag find that running hell is equally challenging. All the deceased sinners (and cats) of the world have been dumped in their laps, little girls keep summoning the devil to grant their wishes, and God keeps sending gay people to hell in a matchmaking attempt to find Lucifer the perfect man!
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Religious parodies/satire. If you enjoyed comedies like Saint Young Men and Hozuki's Coolheadedness, be sure to give Adventures of God a try.
In a time filled with wars, environmental concerns and issues, there lives a gaggle of beautiful boys that are the personification of the world's countries. Japan, England, France, Finland, Germany and the rest of the boys attend the World Conference and tackle issues like global warming with a heavy dose of fun. Through multiple world wars the gang will traverse deserts, build mecha U-boats and solve the world's problems together!
Fujii Yoshiyuki is a single man who works as a cameraman and has found no success in life. At the age of 32, he enrolls at the Buddhist Institute in order to become a Buddhist monk and to take over the temple of his uncle, who has no heir. Despite the Buddhist etiquette he is not familiar with and thanks to his adventures with his new classmates, Fujii's way of life will inadvertently begin to gravitate towards the core values of Buddhism.