If you're looking for manga similar to My Brother the Shut-In, you might like these titles.
Nori, a young girl, looks after her younger brother Take and other people in their neighborhood in Ginza.
Tomoki, a high school student lived with his older sister. What happens when a normal boy has to put up with his sadistic but popular sister?
Aizawa Umi is a good-natured girl who is the youngest of three sisters that live together. Her oldest sister, 21-year-old Sora, is kind of pushy and intimidating, but it's clear that she loves her sisters. The middle sister, Riku, is cheerfully clumsy and enthusiastic about life. Riku and Umi attend high school together, where they both hang out with their friends and Umi tries to handle her crush on a male classmate.
High-school student Kyosuke doesn't get along with his cranky, dismissive, and secretive 14-year-old little sister Kirino, but he finds himself somehow protecting Kirino's secrets — she's not only a fashion model and a great student, but she's got a huge collection of naughty video games and anime! This hilarious, charming hit series is filled with surprises and outrageous laughs. Who says girls can't be otaku, too?
Kairi Shinonome's younger twin brother, Anri, has been dressed as a girl since birth by their mother. One day, Anri goes to an idol audition. Kairi cross-dresses as well to go and stop him, but unexpectedly they both end up scouted as idols!
The manga centers on a set of twins with an older brother and younger sister. The twins were born with a set of odd matching birthmarks on their sides. After their mother abandoned them their stepfather sold them off to a freak show. The story tells what becomes of the twins afterward.