Whether they are the main protagonist or one of a cast of MCs, these manga and webtoons have at least one transgender main character.
A list of manga that has one or more LGBTQ+ main characters. Manga that are BL or GL are not included.
The protagonists in these manga are trans. Gender Bender manga are not included unless the protagonist explicitly identifies as trans in the story.
These manga feature LGBT themes that focus on gender and gender identity, including trans-related topics, rather than the sexuality side of the tag.
A comprehensive list of manga that feature transgender characters and themes. I'm still evaluating some other manga, but if there are any I've left out, or if you find an error, PLEASE let me know in the comments. ...