If you're looking for anime similar to My Friend's Little Sister Has It In for Me!, you might like these titles.
"Puberty syndrome – Abnormal experiences rumored on the internet to be caused by sensitivity and instability during adolescence. This year, Sakuta Azusagawa, a second-year student at a high school near Enoshima, meets several girls that are experiencing this “puberty syndrome.” For instance, he meets a wild bunny girl in the library. She turns out to be an actress on hiatus, Mai Sakurajima, who is also his senior at the school. For some reason, no one else can see this enchanting girl. How did she become invisible…?
Yuuto Ayase is not interested in girls - if his two housemates are anything to go by, girls are loud, brazen slobs that are best left alone. However, when Yuuto accidentally discovers an important secret of his school’s most popular female, Haruka Nogizaka, the two become bound in a budding friendship. All too soon, Yuuto discovers that, despite her flawless appearance, Haruka is clumsy, naive, and a closet otaku... and he just might be falling for her.
As Yuuto continues to keep Haruka’s otaku nature as much of a secret as possible, chaos continues to surround them. With Yuuto’s wild, drunken housemates gatecrashing their trip to a hot springs resort, and Haruka’s sister and maid team concocting various schemes to allow the pair to spend time together, nothing is ever straightforward. While Yuuto does all in his power to make Haruka happy, including working as butler for the tyrannical Touka and pulling an all-nighter to help her finish her first doujinshi, he is unsure as to how the school beauty feels about him. Will the clueless duo finally be able to muster up the courage, and the time alone, to finally confess their feelings for each other?
Yuto and Haruka are looking forward to spending time together on a school trip. However, Shina finally works up the nerve to tell Yuto she has feelings for him. This event drives a wedge between Haruka and Yuto and forces them to confront how they feel.
Teenager Hata Kosaku is crushed when his favorite singing idol, Kusakabe Yuka, stuns the world by retiring from show business. Kosaku’s friends try to cheer him up, but nothing can chase away his gloomy mood until Yuka herself transfers into his class at Tamo Agriculture School!
Miyano spends his days reading Boys’ Love comics—until a chance encounter leads to a scuffle with his senior Sasaki. Intrigued by his feisty junior, delinquent Sasaki uses every opportunity he can to get closer…
After spending his days skipping school and wandering around the city, the delinquent Tomoya met Tomoyo and gradually, the pair fell in love. It has now been a month since they started dating and Tomoyo has just been announced as the newest student council president of Hikarizaka high school. With Tomoyo being kept busy by her new duties as well as her quest to save the sakura trees, and rumors circulating about why the new student council president spends so much time with the school’s two most infamous delinquents, can Tomoya and Tomoyo’s relationship survive?
Yuu has always loved shoujo manga and awaits the day she gets a love confession that sends her heart aflutter with bubbles and hearts, and yet when a junior high classmate confesses his feelings to her...she feels nothing. Disappointed and confused, Yuu enters high school still unsure how to respond. That's when Yuu sees the beautiful student council president Nanami turn down a suitor with such maturity that she's inspired to ask her for help. But when the next person to confess to Yuu is Nanami herself, has her shoujo romance finally begun?
"A girl in a lower grade just made me cry!" One day, Senpai visits the library after school and becomes the target of a super sadistic junior! The name of the girl who teases, torments, and tantalizes Senpai is "Nagatoro!" She's annoying yet adorable. It's painful, but you still want to be by her side. This is a story about an extremely sadistic and temperamental girl and you'll feel something awaken inside of you.