If you're looking for anime similar to Helen Keller Monogatari: Ai to Hikari no Tenshi, you might like these titles.
At the age of seventeen, Takae Tsuneo is electrocuted during his job installing power lines and has both of his arms amputated. However, he decides to devote his life to poetry and literature, and begins to practice writing by holding a pen with his mouth. He eventually gets a job as a newspaper reporter, and turns his attention to other people dealing with disabilities.
Hatta Yoichi is a civil engineer who travels to Japanese-ruled Taiwan in 1910 to build a complex irrigation system in the barren southwest. Hatta manages to overcome the initial doubts of local farmers, but a tragic tunnel accident eventually halts the project and shakes his confidence.
Nitaro's mother passed before he was old enough to remember her, and after smallpox leaves him blind at a young age he finds a connection to her through music and her shamisen guitar. Happily, Nitaro finds out that he has an aptitude for the shamisen and his skills are soon recognized by a goze (a traveling female bard) who takes it upon herself to teach him the traditional style of play. However he quickly realizes how restrictive this style can be and, frustrated, he begins the long journey to find and perfect his own style of play.