If you're looking for anime similar to Genshiken: Second Generation, you might like these titles.
Tsukimi is an otaku and jellyfish enthusiast whose only means of coping with the world is to reject it: she and her friends live in a house they declare a man-free zone, generally avoid 'stylish people', and spend their days blissfully bonding over geeky rituals. As misfortune would have it, their convenient existence is about to be turned on its head by the arrival of Kuranosuke, a seemingly beautiful young woman who is actually a beautiful young man. While he may be strange even by their standards, Kuranosuke embodies everything Tsukimi secretly dreams of being - a princess as ethereal as a floating jellyfish - and promises the kind of mind-boggling adventures only possible when geek meets chic!
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Focusing on a group of older female otaku and a crossdressing boy in their midst, both Genshiken Nidaime and Kuragehime are dramatic and funny all at once. Genshiken's earlier seasons are pretty different from Nidaime, so if you have seen either Genshiken Nidaime or Kuragehime, I'd highly recommend the other.
Najimi Osana's goal is to make a fortune in life, but in reality, she hasn't been having much success in her job. Tsuyuri, a doujin artist and a friend of Najimi, takes her to a convention to help her sell her doujin; and after learning that her childhood friend Justice is a very successful doujin artist, Najimi declares that she will make her fortune by creating doujins of her own. However, Najimi has never created anything close to a doujin before, and will struggle through many difficulties. Together with Tsuyuri, Justice, and Sora, they will work together for Najimi’s sake to gain fame and fortune in the doujin market.
Tamaki Honda, a first year high school student, joins the peculiar SNS Club. With nothing but her wits and her artistic skills, she must traverse the world of doujin (self-published) game development. As new issues arise within the development of game making, Tamaki learns more about her club member’s odd personalities.
A blush-inducing, coming-of-age comedy about manga-loving book store employees!! The characters are all hard-core manga fans and maniacs of some sort, and work at the comic shop "Uma no Hone." On a daily basis, they display new releases, shrink-wrap comics, shudder at their lack of feminine qualities, question their love for porn literature... and basically have fun while working hard (?). Girls and guys call each other by nicknames and some begin to develop close relationships!
This show is centered around Doujinshi (Fan Manga). Kazuki is a senior in high school, who doesn't really know what to do with his future. His friend Taishi drags him into the world of Doujinshi, where he tries to make and sell his Doujinshi to the masses and learn what it really means to be a real Doujinshi artist.
Moeta Kaoruko (Pen name: Kaos) is 15 years old, a high school student and 4-panel manga artist! After moving to a dorm especially for female manga artists, she meets shojo manga artist Koyume, teen romance manga artist Ruki, and shonen manga artist Tsubasa. Every day, they'll work all through the night trying to ink and finish their work! Her cute, funny life in a manga artist dorm is about to begin!
Yuuki Aito is a perverted and hapless author of ecchi manga. Under pressure from his hot-tempered editor, Miharu, Yuuki works alongside his assistants, the long-suffering Ashisu and the enthusiastic Rinna, to finish his manuscript on time. But with Miharu berating Yuuki for taking porn breaks and his insatiable lust for panties, and the underwear-loving mangaka panicking over every ecchi dilemma he faces, keeping his manga out of the bottom of the weekly rankings will be a difficult task…