Dr. Ramune Mysterious Disease Specialist - Videos

main characters of dr ramune are strickingly similar to mob psycho's main characters, and has the same general concept of the main characters taking jobs and helping people in their community (mp100 deals with supernatural things rather than special diseases)

Similar relationship between the main two characters. One younger "straight man" paired with a more unprofessional but still talented man. 

It's difficult not to compare these two shows if you've watched Mob Psycho previously. Dr. Ramune is similar - a blonde, frivolous seeming adult man who actually has a heart of gold with a powerful stoic black-haired middle schooler assistant. They both help clients with supernatural problems. Ramune is more episodic in nature, whereas Mob Psycho has more arc-based storytelling.

Several thousand years after a mysterious phenomenon that turns all of humanity to stone, the extraordinarily intelligent, science-driven boy, Senku Ishigami, awakens. Facing a world of stone and the total collapse of civilization, Senku makes up his mind to use science to rebuild the world. Starting with his super strong childhood friend Taiju Oki, who awakened at the same time, they will begin to rebuild civilization from nothing... Depicting two million years of scientific history from the Stone Age to present day, the unprecedented crafting adventure story is about to begin!

both shows have a similar vibe and portray the effects it can have when the human world and the world of the mysterious clash; 

both shows have a pair of male leads as the main characters who have/develop a deep (non-romantic) relationship;