One day, a man entered a temple that housed forty-eight statues possessed by demons and made a deal: in exchange for ultimate power, they could each take a piece of his soon-to-be born son. Soon after the child came into the world and the demons held up their end of the bargain; the man then left the crippled child in the river to die. Found by a kind doctor, the boy grew older with the help of prosthetic limbs and enhanced senses, but soon demons began to follow him, and the boy - who his new father named Hyakkimaru - left to find a way to complete himself. He searches for the forty-eight demons; each one he vanquishes returns a piece of his body. Alongside the child thief Dororo, Hyakkimaru travels from place to place, hoping to one day become whole.