Story: I've never seen another anime that had the idea of using "alchemy".But like (almost) all shounen/shoujo fantasy animes,a magic circle (in this case, a "transmutation circle") appears whenever the fighting happens.There are many plot twists,and will keep you at the edge of your seat.
Animation: Let me say this looks like it costed millions of yen to create.Considering that studio Bones has made pretty good anime (like Ouran High School Host Club and Black Butler) I would say this is their best animated piece.Metal and blood affects are pretty,smoke is used whenever a explosion happens,and the design of the eyes is simple,yet good.
Sound: As well as a pretty good plotline and Groundbreaking animation,the sound is also good.Explosion sounds are nice.Flames,stabbings,and explosions are nice as well.
Charecters: I haven't seen a Charecter in the entire series that are very similar to each other.Though Ed and Al are brothers,they have very different personalities.
Overall score: 9.8/10