For my first manga of the week, my pick is the delightfully charming Yotsuba&! from Kiyohiko Azuma, the creator of Azumanga Daioh.
Yotsuba&! follows a young girl named, you guessed it, Yotsuba and her everyday "adventures". It may not sound like much, but this is one of the funniest series that I've read. Yotsuba's inherent enthusiasm, optimism, and boundless energy coupled with her naivety and innocence lend to some truly amusing situations. From punching goats, to catching cicada's, Yotsuba gets wholly enthusiastic about every single situation, which accords her a lovable quality - even though you know living next to her would be hell in real life!
Sort of going into too much detail (I'll save that for a future review XD), all I can say is that I laughed so hard at this manga while at work, that had anyone been walking past the door to the office, they'd have thought I was insane. Anyone who enjoys comedy slice of life, because if you miss out on this gem of a manga then you'll end up like this: