Having lived in the same orphanage as children, Takumi Tsuzuki and Fumino Serizawa grew up together and remain fast friends. Now living and working at a bakery, Takumi does his best to prevent catastrophe, particularly when the clumsy Otome is in the kitchen! He attends school with Fumino and is still the only person capable of reading through her baffling habit of hiding her emotions by saying exactly the opposite to what she means. However, the arrival on the scene of enigmatic catgirl Nozomi may force Fumino to be more honest with her feelings than she is used to - or perhaps even able to. This, along with a host of crazy friends and associates such as the stuck-up Chise and the otaku Ieyasu, ensures that there is rarely a dull moment in their lives!
If you want to read something similar, but with much less annoying characters and way less fanservice, then give Come Come Vanilla! a try. While it is almost as cliche as Mayoi Neko Overrun! most of the cast (if not all of it) is quit likable (yes, there are no violent tsunderes or anything like that there).