Kazahaya Kudo and Rikuo Himura are two teenagers who work for the ‘Green Drug Store,' and also rent an apartment above the store. Rikuou rescued Kazahaya from freezing to death on the streets during the winter, and although Kazahaya is grateful to Rikuo for this, the two can't seem to get along. The mysterious Kakei owns the store and Kazahaya often has to put up with the constant teasing of Kakei's friend Saiga. The strangest thing about Kazahaya's job is that he and Rikuo are often sent on "extra jobs" by Kakei, which are different and more bizarre each time. But because he needs the money to avoid ending up on the streets again, Kazahaya never refuses any job offered to him no matter what strange situation he may find himself in. Just what secrets do each of these four men hide, and why is Kazahaya so reluctant to return home?
At first glance, Kimihiro Watanuki appears to be a normal high school student; but little do people know that not only is Watanuki able to see spirits, but he's also a magnet for them! One day, after being chased by one such spirit, Watanuki happens upon a strange building. There he meets a mysterious witch named Yuuko, who claims she can get rid of his ability to see spirits - for a price: Watanuki must work as her housekeeper until he has paid off the cost of granting his wish. Now Watanuki's eyes are being opened to an entirely new side of the world as he assists Yuuko in her work, all while balancing the housework, his schoolwork, and most importantly, ensuring that Yuuko is never out of sake!
As in other Clamp works, xxxHolic does cross over into Legal Drug more prominantly, though there are plenty references to other Clamp works such as Tsubasa, Chobits, and CCS. Moreover, the characters of Domeki Shizuka and Watanuki Kimihiro are so very similar to Kudo Kazahaya and Himura Rikuo,(same template but with a more shounen-ai twist within Legal Drug) as they form this duo of supernatural guardian and medium roles. There are tiny variations between both, such as a seemingly innocuous pharmacy run by a man enshrouded by mystery (Kakei and his pharmacy) versus a wish-granting shop run by a witch enshourded by mystery (Yukko and her shop). Both deal with supernatural dangers or tasks that must be completed by the duo, though each series has its own drama and depth.