After being diagnosed with a mysterious disease, Honoka Kusakabe was put into cryostasis by the scientist Heitarou, her father. However, when she awakens it is not to her family’s loving arms – she is greeted instead by a barren world filled with vegetation and not a single human in sight, save for a dog-like robot named Haco. With his help, Honoka learns about the new world around her and searches for the answers she seeks.
Natsu, Arashi and a few dozen others had gone to bed like any other night when they woke up... somewhere else. In this new post-apocalyptic future, mutated plants and animals lie in every direction and mankind is long extinct. Scientists of the past predicted that a meteorite would strike Earth and render the planet uninhabitable, so they devised a plan: they would cryogenically freeze five teams of young adults and have them revived by a computer when life is again sustainable. Seven people formed each team along with a guide specially trained to survive in the wild, and seven caches of supplies were left to be found. Together, the teams must try to survive in a new and hostile world, inadvertently finding the other survivors and clues to their circumstances along the way.
Medusa is a mysterious illness which causes the body to petrify shortly after infection, found throughout the world and steadily increasing the death toll. After losing his son to the disease, a wealthy gentleman used a large portion of his fortune to turn his medieval castle into a state of the art cryogenic facility. 160 lottery winners were chosen to be frozen until a cure could be found, one of whom is Kasumi - a twin whose sibling was not one of the chosen. Along with a group of others Kasumi awakens from her cryogenic chamber, but not to the same world she left it: prehistoric monsters roam the now-abandoned castle and eat the survivors, while endless giant thorns rise all around them. Against all odds, Kasumi and the others must now try to survive the horror of their situation and discover the truth behind what's happening, all the while waiting for the Medusa to finally claim their lives...
Though King of Thorn is far more dark and serious (not to mention gory), both it and Haco feature a character who was put into cryostasis, only to wake up later to a much different, much less populated world.