Long ago the world was split in two: the realm of darkness inhabited by demons, and a land of light where humans dwell. When the king of the dark world decided to unite the two lands, a war broke out that was ended by a dark knight named Sparda. Now the legend of Sparda is nothing but a fairytale, and while most have forgotten it, the bloodline still lives on. Dante is Sparda’s half-human son who, using his twin guns Ebony and Ivory, works as a demon-slayer for hire. One day, his friend Enzo tells him of a new job and with a hefty reward on the line, Dante accepts. In order to claim his reward, Dante must locate a missing girl named Alice, but when his search leads him to a nightmarish wonderland, he must confront his past as he becomes involved in a plan to break the seal to the demonic realm and engulf the world in darkness once more...
In a land overrun by yoma - monsters that feed upon human innards and take on the appearance and memories of their victims - humans are little more than cattle awaiting slaughter. The only opposition to the yoma is The Organization, a group led by a council of mysterious men who send out their all-female warriors (known as claymores) to do their bidding. However, The Organization is not charitable; a town must pay an exorbitant fee for their services. Likewise, many of the claymores care little for those who they protect. Clare, the lowest ranked claymore, lives only so that she may one day avenge her mentor.
There is no denying that Claymore and Devil May Cry are similar. The main characters (Claire and Dante) are so much alike in their cool self-demeanor and personalities in dealing with the people around them. Not to mention that they both conveniently happen to be half-demon/half-human. They also have a very pronounced soft side that comes through when they are interacting with the children they seem to pick up along the way.
It you like half-humans/half-supernatural being Vampire Hunter D and Devil May Cry take on their own dark tones. With the main characters trying to fight against the forces of darkness and ensure that the good side conquers.