Le Chevalier D-Eon and Blood + are both supernatural and action based series with the main focus centered on the character development and the story of what the characters have to go through. There is a complex mystery in both that gets revealed throughout the series little by little and both of the series have a historical feeling to them.
Blood+ and Tokko have main characters that are thrust out of their daily lives into a whole new type of world. Both have to live up to their own potential and change their own perspective of how to overcome the challenges that face them and the enemies they encounter.
The aspect that I found most striking between Tsukihime and Blood + was the fact that both of the main characters lost parts of their memories. The journey in each series of how they are able to overcome these difficulties and strive for what they are looking for is heartfelt for each character.
Yuki Cross' earliest memory is of snow and blood - she was attacked by a vampire only to be rescued by another. Ten years later and Yuki has been adopted by the headmaster of the prestigious Cross Academy. This school is unique in that it consists of 2 classes - a Day Class and a Night Class. The Night Class is made up of vampires led by Yuki's rescuer all those years ago, Kaname Kuran. Together with Zero Kiryu, a childhood friend who despises everything to do with vampires since his family was murdered, Yuki must serve as a Guardian of the school to keep the two classes separated. Secrets lie beneath a peaceful exterior and not everything is as it seems, as Yuki learns the truth about Kaname, Zero and her own forgotten past.
Strong vampiric-like female leads are seen in both Blood + and Vampire Knight capturing the drama in one single moment. The fighting scenes are similar and there are also strong features coming through in both series that make the background strikingly beautiful.