Not many anime have female leads, here is a list of the ones that I know about. This will also include anime, where there are multiple protagonists.
If you know of one, that is not listed, please...
These titles were voted by Anime-Planet users as the best of for 2008!! http://www.anime-planet.com/forum/showthread.php?t=22708
The shows that have become real masterpieces to me, those I treasure and love very much. Time pasted, preferences changed, but these titles remain in my heart forever
The best of the ending themes from the series I have watched. Not in any particular order. The names of the songs can be found in the "reason" box. (Artist - Song name)
Relatively high priority.