Nakahara Sunako, a high school girl whose interests include horror movies, coffins and gore, is sent by her aunt to live in an extravagant mansion with four ridiculously handsome boys. As if living with these “radiant creatures” who give her constant nosebleeds isn’t hard enough, she soon discovers that the boys have made a bet with her aunt: in exchange for free rent, they will try to mold Sunako into a magnificent lady. As someone who has cast aside all her femininity and sworn to live in darkness, Sunako is ready to do whatever it takes to nullify these efforts; but is there a way for the creatures of darkness and light to coexist?
Kanako Miyamae hates boys so much that she breaks out into hives after any physical contact with them. So when she is able to transfer to the Ame no Kisaki Girl’s school, Kanako is overjoyed that she can now search for her fated yuri partner. When she arrives, Kanako meets Shidou Mariya, a beautiful young girl who is exactly her type... except that Mariya is really a sarcastic and sadistic young boy who is masquerading as a girl! With no intention of being expelled from school, Mariya threatens Kanako into keeping his secret, and decides to guard her twenty-four hours a day to ensure that she does. Now Kanako must share a room with Mariya who is gleefully making her life a misery while using his ‘feminine’ charms to stop her protesting. Throw into the mix Ryuuken, the most popular girl in school who has vowed to protect her; and Kiri - who claims they are dating to prevent her from being bullied - and it seems as if Kanako’s dream of all-girl school life will be nothing like she imagined!
If you like slightly-unconventional female leads who get a lot of comically explosive nosebleeds, look no farther than Maria Holic and Yamato Nadeshiko Shichi Henge.
Both can kinda-sorta be called a reverse-harem (or, at least, a harem with a female lead), with an overwhelming amount of focus going towards the comedic aspect than the romantic. Each heroine is surrounded by very attractive people, and it doesn't look like she'll have a chance.
They share a sort of random, dark comedy.
YNSH is a shoujo anime, whereas Maria Holic is targeted mostly towards a male audience, but if you're fine with either demographic, and you like one series, you shoud check the other out.
Sawamura Seiji is the most notorious delinquent at his high school -- always getting into fights and causing problems, leaving him single and unlucky with the ladies. After another long day of rejection, Seiji discovers that the love of his life might have finally appeared, but in the unlikeliest of places... his right hand?! Now, in addition to dealing with daily fights and the gossip of his classmates, Seiji must handle a new problem of embarassing proportions: Kasugano Midori, a pretty young girl in place of his hand, who happens to have fallen in love with him!
Midori Days has a more of romance-based plot than Yamato in my opinion, but it's funny and cute all the same. Both have the kind of animation I appreciate and a weird/uncomfortable circumstance that sets things in motion.
In order to bridge the gap between humans and youkai, The Ministry of Spirit Affairs was formed. Military man Kei Agemaki is assigned to the new unit and seems to be the ideal candidate. He’s charming, polite, and a complete gentleman, but there’s just one problem: he’s absolutely terrified of spirits! When he arrives at the new headquarters, Agemaki is partnered up with a cute, yet brash, youkai named Zakuro. Now the unlikely pair must work together to solve the region’s spirit-related problems to help improve relations between humans and youkai, and maybe help Agemaki overcome his crippling fear while they’re at it.
Both feature a cast of characters that are very similar to each other--the hot/cold main character and male lead, the stoic, tall male, and the cutesy, young-looking male (with respective partners). If you like anime with these types of characters and the antics that happen because of their personalities, either are a good choice.
While visiting his hometown, junior high school student Michishio Nagasumi's life was changed forever when he nearly drowned. Though he was saved by a mermaid named San, there’s a catch -- her family is part of a merfolk mafia, and they abide by a strict rule: If a mermaid is discovered by a man, either he or the mermaid must die. That is, unless the man marries into the family! Faced with such a decision, Nagasumi can only oblige their customs and become a "happy" newlywed. Now, with a new school year around the corner, Nagasumi must find a way to deal with his new bride, keep her true nature a secret, and most importantly, escape inevitable death at the hands of San's over-protective father’s gang!
Kimihiro Watanuki is cursed with the ability to see evil spirits known as Youkai. Due to this power, the Youkai are attracted to him like a magnet, and each time he is close to being devoured. One day, fate drew him to a strange store and there, he met Yuuko, who was dressed in a very exquisite fashion. As destiny would have it, Yuuko has the ability to save Kimihiro from seeing the Youkai, but for a price: Kimihiro must work for Yuuko by performing chores around the store and other odd tasks, until she deems fit. With his "friend" Doumeki, and his secret crush Himawari, they will discover that the world they live in is nowhere close to ordinary!