In the midst of a fight on the rooftop of her school, Mikami Inaba is involved in a freak accident. Desperate to save a cage of cute rabbits from falling to their demise, Mikami grabs at the first rabbit she can reach; but during the fall, a flash of magical pink light envelopes her, fusing her with the rabbit and giving her a new voluptuous appearance and loving personality! This alter-ego is named Mimika, and is now her primary form. However, Mikami is as wild and tough as ever, still lying beneath the cute exterior and waiting to regain control of her body when she or her friends are threatened!
Six years ago, a catastrophic event ravaged Tokyo. Amaha Masune was found at ground zero, physically unscathed, but without memories and with a child in her arms. Returning to Tokyo for the first time since the disaster, the slightly clumsy but cheerful Masune just wants make a new life and to raise her daughter without interference from the Child Welfare Agency. But unsolved murders are being committed all over Tokyo and a near-miss reveals her identity as the bearer of the Witchblade, a mysterious weapon linked to the disaster 6 years before, that seems to have a mind of its own. Giving in to the Witchblade seems dangerous, but when the powerful Dohji Corporation agrees to guarantee her a life together with her daughter if she works for them, can Masune pass up the chance?