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The development of the Infinite Stratos powered exoskeleton changed the world’s balance of power. While the distribution of IS systems has created peace, only women have been able to pilot them. So when Ichika Orimura is discovered to be the first male with the ability to control an IS, whatever plans he had for his future are tossed out the window even as he’s thrown to the wolves and enrolled at the otherwise entirely female Infinite Stratos Academy by order of the Japanese government!
Funko, Shigu, Eru and Ichiroku seem to be typical school girls on the surface, but they're actually powerful, dangerous guns that must be treated with care and respect! Together, they attend Seishou Academy, a special place where not only are all of the students guns, the teachers are as well. That is, except for one new educator who arrives, unaware of the crazy, dangerous times that lie ahead!
The year is 1973 when the BETA, a race of aliens discovered on the moon, first arrive on Earth and begin their systematic extermination of the human race. Mankind's only hope lies with Tactical Surface Fighters, or TSFs, piloted by both military elite and would-be trainees such as Yui Takamura, a young girl descended from a long line of Imperial Guards. Alongside other amateurs, she finds herself on the front lines of a final defense against the bloodthirsty monsters, unaware of the brutal consequence that awaits them. Three years later, Yuuya Bridges, a half-Japanese, half-American pilot, is assigned to an elite United Nations squadron tasked with developing new TSFs to beat back the alien forces. As humanity struggles to survive, Yuuya must come to terms with his biases in dealing with both his teammates' and other culture’s tactical fighters, including the veteran pilot Yui Takamura herself.
The story is set in a peaceful time on a dreamlike world entirely made possible by science. Five years ago, the world's energy crisis was solved with the creation of the "Manifestation Engine." Akane is a 14-year-old girl who lives an impoverished but happy life with her little sister and grandfather. However the tranquil daily life that Akane enjoys is shattered by a threat, and she vows to face it in the red battle suit that wields immense power.