Not many anime have female leads, here is a list of the ones that I know about. This will also include anime, where there are multiple protagonists.
If you know of one, that is not listed, please...
The ones that I get the urge to rewatch.
These titles were voted by Anime-Planet users as the best of for 2008!! http://www.anime-planet.com/forum/showthread.php?t=22708
These are Anime that I think everyone should check out!
This list has all animes which I have given 5 stars. This list is not in order, so you all know it. And another thing, I do not have seasons together in this list.