Natsume is lonely; he has an ability that separates him from others: he can see and interact with spirits. Soon, however, Natsume discovers that he’s not alone: his grandmother Reiko also had the gift. But things get hectic and possibly dangerous for Natsume when he finds out that he also inherited the 'Book of Friends', a book that contains the names of all the spirits Reiko defeated and subjugated. He finds himself hounded by his grandmother's underlings and, with the help of a 'cat' charm spirit, decides to free them from the Book's shackles, as well as protect the book from those who seek to misuse its power...
In feudal Japan, evil spirits known as mononoke plague both households and the countryside, leaving a trail of fear in their wake. One mysterious person has the power to slay the mononoke where they stand; he is known only as the Medicine Seller, and he vanquishes the mononoke using the power of his Exorcism Sword. However, in order to draw his sword he must first understand the Form, Truth and Reason of the mononoke. Armed with a sharp wit and keen intellect, the Medicine Seller wanders from place to place, striking down the mononoke in his wake.
Tadayasu Sawaki and his long-time hometown friend Kei Yuuki are finally away from home and ready to start university. They attend Tokyo's College of Agriculture, and the adventures start from day one! But that is to be expected, as Tadayasu has a special ability that is conducive to adventure and glory, especially in the world of agriculture and biology: the man can see, communicate, and interact with microbes! With ambitious sake-brewing upperclassmen, a sadistic postgraduate, and a clean-freak colleague, things can only become more exciting for the duo!
In both animes, the main character is able to see things normal people can't.
Moyashimon focuses more on comedy and Natsume is in my opinion far superior in both story and art, but both are worth a watch.
Everyone around Kousaka seems to adore cats, but due to his allergies the teen can’t stand them. So when he wakes up one day and can hear what every feline is saying, Kousaka is annoyed to say the least. His new “gift,” it seems, is the result of accidentally breaking an enshrined statue of a cat; and what’s worse, Kousaka must atone for his sin and appease the vengeful spirit by aiding one hundred kitties-in-distress, or become a furry feline himself! Now, amidst helping various cats with mundane and trivial issues, Kousaka must try to dispel the jinx and attempt to salvage his self-respect – not to mention his love life - along the way.
Ouran High is a school for the extremely wealthy or, in Haruhi's case, the extremely talented. But no amount of talent will help when Haruhi accidentally drops an eight million yen vase in a music room. The vase was the property of Ouran High School Host Club, a group of attractive young men who, for a fee, provide their time and affections for their lovesick clientele: the female students. Fascinated by this strange new specimen, a poor and clumsy commoner, they force Haruhi to work for them until the debt is repaid; but they get a lot more than they bargained for...
In modern Japan, Tokyo is expanding and considerably reducing animals' habitats, including those of the tanuki (raccoon-like creatures). What humanity doesn't know, though, is that tanuki are intelligent creatures, that can talk and even walk on two legs with the power of transformations! To secure their survival, the two combating tanuki clans join forces against mankind in a war they dub 'Pom Poko'! Humans are a difficult adversary, though... can the tanuki open mankind's eyes to the beauty of nature, before their homes are replaced by yet another suburb?
Both Pom Poko and Natsume Yuujinchou focus on the relationship between supernatural characters and humans. While Pom Poko is told from the view of the Tanuki and Natsume Yuujinchou focuses more on the human aspect, both are compelling and steeped in Japanese mythology, so if you are interested in that, then you may well enjoy both of these anime.