Tadayasu Sawaki and his long-time hometown friend Kei Yuuki are finally away from home and ready to start university. They attend Tokyo's College of Agriculture, and the adventures start from day one! But that is to be expected, as Tadayasu has a special ability that is conducive to adventure and glory, especially in the world of agriculture and biology: the man can see, communicate, and interact with microbes! With ambitious sake-brewing upperclassmen, a sadistic postgraduate, and a clean-freak colleague, things can only become more exciting for the duo!
In the future, aliens coexist freely with mankind on Earth. One such alien is NieA, a lazy yet spirited girl who wastes away her days while living with the studious Mayuko. And life isn't easy... Mayuko is always short on food money, the spa where she works is about to go bankrupt and Mayuko's alien-crazy friend Chiaki is obsessed with NieA. A light, mostly comedic slice-of-life show.
If you're willing to accept (and appreciate) the general weirdness of either Moyashimon (I can see germs!) or NieA_7 (This city is full of crazy aliens but that's totally normal!), then you'll likely like the other.
Both are definitely-not-mainstream slice of life series about poor college students and their unusual circumstances.
The studious and uptight Chiaki is well-known as the top pianist of his school, and dreams of becoming a world-class conductor like his idol, Viera; but his fear of flying (which makes studying abroad impossible) combined with a recent break-up and dismissal from his piano instructor causes that future to seem both bleak and unlikely. After collapsing outside of his apartment, drunk, Chiaki inadvertently meets a young woman named Nodame who, while quite talented at the piano, is unclean, clumsy, and haphazard. Despite being almost polar opposites, the two begin to grow closer and work, together, to overcome the obstacles in their careers.
While both anime are a specialized comedic twist on the slice-of-life genre, they both prove to be very unique and can be appealing even to those who may not find anime with a school setting very interesting. At the same time, if you're a university student or can appreciate aspects of college life these series may appeal to you, as they both take place in/around a college.
The personalities found in both Moyashimon and Nodame Cantabile are a bit over the top, but are still very unique. Each of the cast characters are hard-working (most of the time) and have incredible talents that you don't find in most students. While the comedy is mostly slap-stick and a bit over the top, both are semi-educational in that Moyashimon and Nodame feature a plot around microbiology and classical music, respectively.
In other words, if you like anime that teaches you a little something new while focusing a funny cast with unique talents, both shows should strike the nail on the head.
The eccentric Suzumiya Haruhi wants nothing more than to meet aliens, time travelers and espers… but she’ll have to settle for the everyday Kyon instead! Along with the mysterious Itsuki and the vacant Mikuru, the duo forms the SOS Brigade – a club whose mission is to discover the mysteries of the world. Armed with a razor sharp wit and a skill for manipulation, Haruhi will stop at nothing to have fun at all costs, even at the expense of Mikuru’s dignity!
Moyashimon is a unique anime, and I found its mix of interesting, flawed characters, put in bizzare and amusing situations, a great recipe for some hilarious comedy. It's from this very general take that I recommend the Melancholy of Suzumiya Haruhi, as both of these anime are very unique and distinguished. Oh, and they both have supernatural aspects...
Shinichiro Nakagami is an everyday high school student, with the exception of having his beautiful and athletic childhood friend Hiromi Yuasa living in his household after the death of her parents. Unfortunately, their relationship is cold at best - Shinichiro can tell that she is suffering, but she acts coldly and distant from her foster family and so he is unable to help ease her sadness. His family is also forcing him to practice a traditional Japanese dance that does not interest him, adding to his frustration. On top of that, he is cursed to misfortune by another girl in school, the eccentric Noe Isurugi. Shinichiro juggles all of these problems on a day-to-day basis as he learns about love and the sadness of those around him.
An odd recommendation at first, but forget the 'gimmick' of Moyashimon, the bacteria, and what you see would be an interesting look on human emotions, expectations and future. The realism with which it is done isn't far off from the emotional exploration that is True Tears.
If it was the bacteria you fancied in Moyashimon or the tears in TT then, although still worth a try, don't pay much attention to this recommendation.
Self-professed lover of all things small and cute, Souta Takanashi finds himself dragooned into working at the Wagnaria family restaurant by the diminutive and vivacious Poplar Taneshima. Though the pay is reasonable and the clientele polite, the high school student is often at his wits' end when dealing with the quirky staff. If the indifferent and street-tough manager, katana-carrying floor chief, and terminally weak Poplar weren't enough, Souta frequently fears for his life, as every encounter with the violently androphobic Inami ends in injury. How long can he survive before the combined stress and harm do him in?
Each series is both highly entertaining and funny at the same time with each series using somewhat similar humor to make the viewer laugh and just overall enjoy the series. Both series also carry this very easy going type of flow to them with the cast in either series pretty much never getting serious. Each series also has somewhat similar cast of characters that bring their own individuality to each series. If you liked one of them then you'll probably like the other as well.