Alice was a beautiful woman who betrayed the wrong man and died, and as a result of her actions, the man (a mad scientist) decided to resurrect her. Using the skin from his brain, heart, and "love organ", he spent sixty years designing his beloved's new image and purpose: to be men's eternal sex slave. Fast forward to the present, and the man is on his death bed. He charges Don Jirochou, his adopted son, to hunt down Alice and kill her for her betrayal. And so, Don sets forth to find Alice and put an end to her - but not before he puts it IN her as well, multiple times!
Lupin the 3rd is the world's greatest thief, and a master of disguise. He is also the world's greatest womanizer, who never misses a chance to spend intimate time with a girl (something that is practically guaranteed to get him in trouble). Constantly persued by Interpol's Detective Zenigata, Lupin always ends up on top and with panache.
Well, the same studio created both Lupin and Alice, and it shows. The character designs are remarkably similar, though admittedly Alice looks absolutely horrendous in comparison. Each has a suave leading man who is great with the ladies, and the same kind of campy feel; the only difference is that Lupin is decent and a classic, while Alice is pretty much the worst anime ever. If you liked one, you may enjoy the other - just keep the difference in mind.