If you're looking for anime similar to Mass Effect: Paragon Lost, you might like these titles. All recommendations are made by Anime-Planet users like you!
The fight against the Covenant continues, touching the lives of countless soldiers and innocents. Discover the legends of a group of SPARTANs that must intercept an invaluable package; a lone soldier who struggles with the demons of his past; four Orbital Drop Shock Troopers that must assassinate a Prophet with the help of an unlikely ally; and many other heroic and tragic tales.
Witness the true beginning of the Matrix: how men created the machines and how those machines stood up against their masters, and the effects of the great war that waged between them, which in the end led to the fall of mankind. Watch the ship Osiris and its efforts to warn the remaining humans of the imminent attack; follow a champion who happens to break free from the Matrix; explore the exploitation of a glitch in the overall system; observe the story of the Kid and how he was found by Neo; travel with an investigator who tracks the well-known hacker Trinity; and learn the secrets of the Matrix in other wondrous ways.
Both are anime adaptions of science fiction originating from outside of Japan, and could be considered to be fairly niche, depending on viewer taste. Although a long shot, the same sci-fi ambience is still present in both titles. Also, it helps for each title if you've seen the original products of the adaptions; play Mass Effect 1 & 2 before watching Paragon, and view the first Matrix movie before seeing Animatrix.