After nine year-old Melmo loses her mother in a car accident, she is left to care for her two younger brothers, a task far beyond her age or means. However, in the midst of her grieving, Melmo is visited by the ghost of her deceased mother who gives her a bottle of miraculous candy, capable of transforming her into either an adult or an infant. A combination of the two can reduce her to a fetus and then change her into any animal she imagines. Drawing on a seemingly inexhaustable supply, Melmo uses her candies to solve the various problems thrown her way, aided by her younger brother Toto and her cantankerous mentor, Dr Nosehairs.
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