In the distant future, the harmony of the galaxy is threatened by ESPers who use their psychic powers for violence and criminal gain. However, there are those ESPers who hunt down and put a stop to these criminals under the Galactic Patrol System Cosmo Police; Justy Kaizard is one such man. After defeating the powerful Magnum Vega, his daughter became like a sister to Justy - her memories locked away and her mind still that of a child's. Soon, Justy will face his hardest mission yet: to save his sister from the clutches of Magnum Vega's gang of ESPers, who wish to use her as a tool to take down Justy for good.
Both anime take place far into the future and feature characters with psychic powers. The hero is the most powerful esper in the universe and is tasked with stopping other espers who are using their powers to cause trouble or commmit crimes.
I actually thought for a momen that Quon WAS Locke, they both have the same "ESPer" haircut. However besides seeming to have lived for an EXTEREMELY long time, they are different. Which means more ESPer anime.
Both deal with a character that's lived for almost ever and how they interact with other ESPers and how they deal with non-ESPER people. Bother series/OVA sets also take fighting against organizations out to either destroy all humans or destroy all ESPers. Only Locke get more action have different storylines, while Quon gets one continuous one.