Not many anime have female leads, here is a list of the ones that I know about. This will also include anime, where there are multiple protagonists.
If you know of one, that is not listed, please...
basically anything with elements of fantasy, whether it be mythical creatures or nonexistent things.
This is a list of English dubbed romance anime. I've listed them in alphabetical order.
Yeaaa, surprise! Sexism. Fun fun... I'm just trying to warn you about these anime if you're sensitive to that kind of thing.
This is a list of some of my favourite animes in no particular order what so ever.
Mostly for Summer, but my MAL challenge list.
Anime series with older men and sometimes younger women.~
Anime which weren't quite important enough to make it to High Priority/next year's challenge, but ones which I still want to see. Movies are likely to be watched first out of these.