Not many anime have female leads, here is a list of the ones that I know about. This will also include anime, where there are multiple protagonists.
If you know of one, that is not listed, please...
Every single of my plan to watch anime is in this list alphabetically.
A list of anime I can actually watch on Crunchyroll
Unlike my cutesy list, here I plead that the characters are moderately cutesy, but that the focus isn't on those parts. Therefore, it's action/romance. It's hard to explain. Take the list with a...