Not many anime have female leads, here is a list of the ones that I know about. This will also include anime, where there are multiple protagonists.
If you know of one, that is not listed, please...
Every single of my plan to watch anime is in this list alphabetically.
These are Anime that I think everyone should check out!
From Barely Kawaii to too much Kawaii
Short comments for all the anime I've watched. A constant work in progress.
Note some of these shows have low ratings because they are at times confronting.