If you're looking for anime similar to Hoshi no Orpheus, you might like these titles.
Michael is a young oboist at a conservatory and a talented gardener, but as he prefers the greenhouse to the obo his skills as a musician are lacking. He saves a potted plant and is thanked by Florence, the flower's fairy. She gives him the Semper Wand, which allows him to follow her into Flowerland – a world populated by a whole host of creatures, including a mischievous goblin who wants to conduct with the Wand. It is a world of wonder, ethereal beauty and music - but is threatened by the changing of the seasons. Can Michael save this world? Does his music career have a future?
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Yousei Florence, like Hoshi no Orpheus, is a Fantasia-esque anime from Sanrio. I thought Florence was considerably better, but if you enjoyed Orpheus - or wanted to but were disappointed - you may like this film.
In the ancient time of the gods, a son of the titans was born: Arion, borne of Demeter and Poseidon, the lord of the sea. After being kidnapped to the realm of the Underworld by Hades, Arion is sent on a mission to destroy Zeus, the lord of the heavens, in retribution for causing his mother's blindness. In his quest, he will gain new friends and face the powers of the gods themselves as he struggles to strike down Zeus and save the one he loves from the evil Apollo.
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Unico is a special unicorn with the ability to make anyone he meets happy. But the gods are not pleased, and out of jealousy, they bid the West Wind to exile young Unico to the Hill of Oblivion, where he shall stay, alone, forever. Luckily, the West Wind is a kind soul and instead, hides Unico away from place to place, keeping him shielded from the eyes of the gods. Along the way, Unico must make new friends and even save the world from an evil power!
Pollon is the sweet daughter of Apollo, the god of the sun. Wanting to prove herself of being a worthy goddess, she trys to become one by doing kind deeds, but always fails to succeed causing much trouble for the other gods and their human subjects.
A young religious student from the 25th century and a girl from the 30th century travel through time, witnessing famous scenes from various world religions. They observe the battles of the Greek god Hermes, Moses parting the Red Sea, the miracles of Shakyamuni Buddha, Jesus Christ's death and resurrection, and the enlightenment of the legendary Chinese monk Chih-i. The children are taught how all of these people, as well as all of humanity, are connected to each other in the great flow of time.
It is the 31st century, and mankind has taken to exploring the stars. Ulysses, captain of the spaceship Odysseus, takes his son Telemachus on a space journey for his 12th birthday. When the children onboard the ship are kidnapped by an alien race to be sacrificed to a giant Cyclops, Ulysses rescues his son and in turn angers the Gods. His interference is punished severely – his entire crew are left frozen in stasis, and his ship’s computer, Shirka, has her memory erased so she can no longer plan a route back to Earth. Cast into the depths of space, Zeus commands Ulysses to find the realm of Hades before being allowed to journey back home. Along the way, the scant crew meet travellers who have felt the wrath of the Gods, and others who have been commanded to impede or even kill those onboard the Odysseus. Will Ulysses ever make it home, or do the Gods have a much more twisted plan in mind for the space explorer?
In time of heroes and gods, Kurt, a young prince blessed with inhuman strength, sets out on a journey to restore his mother who was turned into a statue by the monster Medusa. Armed with a magic sword and guided by a golden eagle he travels to the Land of the Dead where Medusa resides in order to find a cure and to defeat Medusa.