In the mid 1800s, prior to the fall of the Tokugawa Shogunate, two men lead very different lives in the city of Edo. Ibuya Manjiro is a would-be samurai who refuses to back down from a fight, and Ryoan Tezuka is the son of a well-known doctor and student of Western medicine. Both are looked down upon by members of the community – Ibuya for his heroic behavior that makes his dojo look bad, and Ryoan for following a form of medicine that Japan, as a whole, shuns. Though the two are on very different paths, their lives inevitably cross in romance, times of need, and the changing of history...
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