Henrietta is a young girl who works for a "welfare group" that does the government's dirty work. Cybernetically-enhanced and specially-trained, she is one of a group of elite hit-girls, remorseless killers with no memories of their past. Jose, her partner, has taken care of her since she was brought into the organization following the murder of her family, and struggles between his affection for her, and his opposing duty to his employer. But, time is running out.. for with each bullet they fire, Henrietta and the other girls lose a little more of their humanity.
In times of olde, humans live in constant fear of demons known as yoma. These vicious creatures can take the appearance and memories of humans they have devoured, thus blending into society as they freely feast on human flesh. The key to stopping the yoma lies with the tolerated yet feared Claymores - women who are half-demon, half-human, and fully fated to become the demons that they hunt. Meanwhile, in a village, the young Raki has been banished; his only crime was losing his family to the yoma. Raki is drawn to a Claymore named Clare, and together their journey begins. While Clare fights the yoma plaguing the land, can Raki help her in her struggle to retain her humanity?
Both Gunslinger Girl and Claymore have young girls/women who are modified to become incredible killing machines. However, the true appreciation for both lies in the ethical and moral dilemmas these modifications have done. These girls/women have their lives shortened, have morally questionable relationships with their handlers (Fratello in GG, The Organization in Claymore), and generally lead bleak lives masked by facade of innocence or indifference.
That being said, these problems are actually what makes both of these series so much better than your typical "girls with guns/swords" shows. GG and Clannad rank among the best anime series I've watched.
In the year 2016, a catastrophic incident at the Odaiba nuclear power plant contaminated the city with radiation and turned Tokyo into a ghost town devoid of life. 20 years later, Japan still struggles with the environmental consequences of that fateful day, and actively looks for survivors using Coppelions: genetically-engineered, radiation-resistant girls who scour the streets when SOS calls occur. With military support and funding to back them up, these young ladies continue to explore Tokyo and discover just who, and what, managed to survive.
Genetically altered young girls are put into dangerous situations that forces them to mature quickly. The plots of the anime are quite different, but the characters make these shows a good match for each other.
Gunslinger Girl is much more serious with less comedy moments, but both shows have an atmosphere of despair.
Joe Shimamura is one of nine humans abducted and experimented upon by the mysterious “Black Ghost” organization. Awakening to find he has super powers no mere mortal could possess and the name of Cyborg 009, Joe escapes from the lab to meet up with the other eight humans that escaped. Together, they join forces to stop the mad scientist Dr. Gilmore, their creator, and Black Ghost itself. Can they prevail against this nigh unstoppable enemy before the world falls into their villainous control?
Gunslinger Girl and Cyborg 009 might have different plots but the premise is the same. Normal human beings are basically taken away by a mysterious organization and are given new parts to amplify their abilities and become superhuman.
As cybernetic technology advances, criminal activities are becoming daily common occurrences. For Chief Aramaki and his ELITE squad, Section 9, they are the only ones with the means to put an end to cyber terrorism. Join Togusa, Ishikawa, The Major, Batou, and the rest of the Section 9 team through a intellectual roller coaster ride in the 21st century.
Duke Tougou - otherwise known as Golgo 13; he's loved by the ladies, hated by his enemies, is enamored with firepower, and can take out a target from several kilometers away. With an arsenal of weapons at his command, Golgo 13 is hired by a variety of people to take down hijackers and more - but he also must protect himself against those who want to take down the legend himself!
Professional assasins! Both shows are not about Ninjas, but rather modern-day, gun-armed killers. There's a curious simularity between the principal characters, too: they do not feel the slightest remorse for what they do. This is because the Gunslinger Girls have been brainwashed, and because Golgo 13 has a completely inscrutable personality--we never learn his motivations. In both cases, killing people is just a job, nothing personal, you might say. Also, both shows delve into the dark underside of society--crime, corruption, etc. There are no "good guys" in these shows, which is an original and intriguing dramatic technique in itself.