Once upon a time, two brothers passed the happy days of their childhood by studying alchemy, which is governed by the equal transfer principle: an eye for an eye -- you can't get more than you give. But these brothers tried to defy that law, and a horrific accident resulted. Now, the older brother, Edward, is called the Full Metal Alchemist because of his metal limbs, and the younger, Alphonse, is a soul without a body, trapped within the confines of an automaton. Together they search for the power to restore themselves, to find the lives they lost so long ago...
Both shows are about two brothers on a mission (one to find a way to get their bodies back to normal, the other to find their dad and hunt monsters along the way). Both focus on the bonds between the two brothers with plenty of action and intrigue along the way. Although, honestly, the Supernatural anime doesn't to the live action justice, it's stilll an entertaining enough watch.
Tales of Vesperia uses the old "Dog of the Military" idea where someone is considered restricted by their orders. Yuri and Ed both follow their own instincts in order to do what they think is right. If you like the idea of watching characters break past boundries and over come odds then you'll enjoy both of these.
Fourteen years ago, an environmental disaster known as the "Hammer of Eden"” devastated the planet – taking with it six billion lives, and submerging 90% of the world underwater. In the present, the remaining countries have formed a new United Nations in hopes of peace. Gould, a submarine captain, wishes to use military force to obtain this goal, while Aoi, the secretary general of the UN, believes in the power of diplomacy. In this world, Keel and Teen are twin siblings who, through a series of events, travel separately with Gould and Aoi. Together, they seek to answer the same question: is war the only way to attain peace, or can people learn to set aside their differences and negotiate?
Not only do the main characters in Fullmetal Alchemist, and Tide-Line Blue look very similar, the theme of each anime are also very similar. War, government corruption, and main characters who are willing to oppose authority are central to each. Both anime ask the question, how far are you willing to go to get what you want. If you like one, you will like the other.
The power to cross over dimensions is one that is deeply coveted -- a lesson that childhood friends Sakura and Syaoran learn the hard way when an unknown enemy attacks an archaeological dig in their country. As a result, Sakura's memories are scattered to different dimensions, causing her to fall into a deep sleep. In order to save Sakura's life, she and Syaoran must journey to various worlds in search of her memories, with the help of fellow travelers, Fai and Kurogane. But finding Sakura's memories won't be easy, and the price for traveling through time and space is high...
The main characters in both of these series are striving to regain what was lost of their loved one. While knowing they will face many hardships, they embark on a journey in which they meet new people and learn many different things. The main characters are also supported from many other characters when the time is needed.
Akiyuki lives on post-war Sentan Island, always rushing between the demands of his separated parents and his friends at school. But his carefree days come abruptly to an end when his school bus suffers an explosion, the first attack to plunge Sentan back into war. Akiyuki lives to find himself turned into a Xam'd, a mysterious creature, by the suspected cause of the explosion. Engulfed by Xam'd, Akiyuki is eventually saved by a red-haired girl, Nakiami, only to find himself torn away from those he loves. Now he must work to control and understand the creature within him, all while searching for his family and friends in a world steeped in the secrets and chaos of war.
The two shows share alot in common visually and both shows heavily focus a military thats conducting human experiments in turning humans into weapons.
Tone wise, the shows are very similar as well. Both of have a similar blend of drama/tragedy and really try to tug at your heart strings the whole time. FullMetal Alchemist has more action, while Xamd has more feel good moments.