The foundation of alchemy is based on the law of equivalent exchange; you cannot produce something from nothing. As such, alchemy is bound by one taboo - human transmutation. Four years ago two young brothers, Edward and Alphonse Elric, broke this taboo when they tried to resurrect their dead mother. During the process Al's body disintegrated and Ed lost his leg. In a desperate attempt to prevent his brother from disappearing completely, Ed sacrificed one of his arms so he could affix Al's soul to a suit of armor. When his missing limbs are replaced by auto mail parts, Ed bears the name of the Fullmetal Alchemist - the youngest ever State Alchemist and dog of the military. Now, alongside his brother, Ed uses his status within the military to attempt to find any way that he can return their bodies back to their original state.
In the future, a system called Sibyl presides over the country and provides order to every facet of life. It dictates which job fields citizens should go into based on aptitude tests, and can even read each resident's mental state and predict which ones are likely to commit crimes in the future. Fresh from exams, Akane Tsunemori is beginning her career as an Inspector, a specialized police officer who works to apprehend these latent criminals and stop crimes before they happen. But not all that get caught are eliminated or jailed, some join the police force as Enforcers to provide insight into criminals’ minds, and Akane is warned not to get too close to them, as they're considered little more than hunting dogs. Though skeptical of this advice, and Sibyl's judgement, Akane is determined to work together with her Enforcers to protect the peace of her city and its inhabitants.
Both take place in unique worlds of their own with societies run in questionable manners, causing the characters to consider what is right and wrong in their culture and what they can do to affect it. Different they may be, but both series are entertaining, intense, and worthwhile for anyone to watch.
Ten years have passed since the demise of the bubble economy, a time that polarized the world into two groups of people: the rich and the poor. In the present day, Saiga Tatsumi (a former war photographer) has been hired to investigate a secret club for the rich named the Roppongi Club, but he soon discovers secrets much darker than he’d ever imagined. With the help of a exploited goddess named Kagura, Saiga now possesses the power to kill by simply taking a photograph; but can he stay alive long enough to save her from her captors?
“Vash, the Stampede” - worth 60 billion dollars to the one who can turn him in. Bounty hunters everywhere are on the lookout for this legendary gunman, not to mention insurance agents Meryl Stryfe and Milly Thompson, who are tasked with preventing any potential damage that this Vash can cause. But with 60 billion on his head, Vash is not an easy man to find.
Both anime take a serious tone added in with laughter to lighten the mood of the story. Great characters and settings are found in both. The characters while wild and silly have a nice serious side to them that doesn't ruin the parts in the series that are suppose to be serious. If you liked one check out the other.
In a world where humans are enslaved by beast men, there is one person who wishes to destroy it all: Morute, the leader of the World Destruction Committee. She sets out on a journey with an ancient artifact known as the "Destruct Code," a device rumored to have the power to destroy the world and turn everything back into sand. Along the way she finds two companions: the kind-hearted human Kyrie, and aspiring hero and beast man Toppi. Together the trio travels the world, always staying out of reach of the World Salvation Committee. Will they discover the secrets of the Destruct Code, and more importantly, succeed at destroying the world?
Both of these anime involve a journey of self discovery, quirky and interesting characters, and fantastic world settings. Both anime also spend a lot of time on world-ending endeavors. Both of the protagonists would fall into the "Grumpy Hero" category and have suffered some major trauma in their life.