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Tatsuhiro Sato is a university dropout and a "hikikomori" – a person suffering from social withdrawal. To Sato’s dismay, his self-imposed exile from the world is rudely interrupted when a mysterious girl knocks on his door. She has charged herself with the task of curing Sato of his hikikimori ways! Now, as new problems ranging from hentai games to internet suicide spring up, can Sato manage to overcome his hermit-like ways, or will the imaginary N.H.K conspiracy force him to remain a hikikomori forever?
Haruka Kotoura has had a psychic ability to read minds since she was born, but her inability to grasp that she's different has led her to be ostracized by every friend she's made. When she meets Manabe, she can't help but be surprised - when he's not imagining strange creatures dancing through the desert, the boy is a hopeless pervert and makes no attempt to hide his dirtiest fantasies. What's more, Manabe isn't driven away by Kotoura seeing his thoughts, and even goes out of his way to befriend her - seemingly because he enjoys thinking of the girl erotically and seeing her subsequent embarrassment! Before long, the once-lonely girl even meets other students who aren't pushed away by her abilities. Could this be the start of a normal school life, with real, lasting friends for Kotoura?
Kotoura-san is about an emotionally-damaged, socially-isolated, mystically-inclined female protagonist with a cruel mother who is adopted into an unconditionally accepting nakama. Fruits Basket is about an unconditionally accepting female protagonist with a saintly mother adopted into an emotionally-damaged, socially-isolated, mystically-inclined nakama. Though (or, perhaps, because) they are near perfect reversals of each other, they seem to hit similar emotional chords or at least operate in the same key.
Fruits Basket is more strictly shoujo, while Kotoura-san is targeted to both male and female viewers.