Not many anime have female leads, here is a list of the ones that I know about. This will also include anime, where there are multiple protagonists.
If you know of one, that is not listed, please...
basically anything with elements of fantasy, whether it be mythical creatures or nonexistent things.
The ones that I get the urge to rewatch.
Every single of my plan to watch anime is in this list alphabetically.
Not including SOME sequel series, follow-up OVAs or specials. They will be counted along with the parent series.
Some of the shows I watched back in my earlier phases of being an anime fan. These shows were pretty much what got me into anime, and they give me such a nostalgic feeling!