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Natsume is lonely; he has an ability that separates him from others: he can see and interact with spirits. Soon, however, Natsume discovers that he’s not alone: his grandmother Reiko also had the gift. But things get hectic and possibly dangerous for Natsume when he finds out that he also inherited the 'Book of Friends', a book that contains the names of all the spirits Reiko defeated and subjugated. He finds himself hounded by his grandmother's underlings and, with the help of a 'cat' charm spirit, decides to free them from the Book's shackles, as well as protect the book from those who seek to misuse its power...
Tomoya Okazaki is a third-year high school student who is generally bored with life and doesn't take his studies, future, or anything else seriously. One day, however, he meets a lonely-looking girl in the school courtyard, Nagisa Furukawa. She explains to him the source of her loneliness: she had missed a lot of the previous school year and thus is repeating her third year; everybody that she knew has already graduated, and she is lonely. Tomoya is rather indifferent at first, but decides that he has nothing better to do and spends increasingly more time helping Nagisa restore the school drama club. As his relationship with Nagisa grows, Tomoya begins to open up to various other people around the school as well...