Holding strictly to his family's creed, Kou Ichinomiya has never once, in his life of privilege, owed anything to anyone – that is, until a self-proclaimed Venusian named Nino saves him from drowning in the wake of a dire accident involving Kou's pants. Eternally indebted to the supposed extraterrestrial, Kou moves into her little community under the bridge along the Arakawa river. Ripped from his life of luxury and success, the young Tokyo U graduate now must adjust to his well-appointed hovel, strange new neighbors, and peculiar lover, Nino.
What do you do when the Emperor of Japan has been replaced with... an alien from Planet Octopus?! From intense motorcycle races to crazy machine inventors from Holland, from sea voyages to battles about emo trading cards, there's never a dull moment in the life of the bizarre. Join an eclectic cast as they are visited by a Ramen Fairy, are reincarnated over and over, solve cases like detective pros, and overall have a laughably ridiculous time!
Haré and his mother live peacefully in the jungle, until one day the boy is overtaken by a omnipotent shadow. Later, he awakens to find Guu, a strange girl with even stranger abilities - notably, the ability to switch from a cute, lovable Guu, to a menacing delinquent who eats everything. Now Haré must live with Guu, and lead a normal life, despite her oddities.
Like the interplay between the "normal" guy who freaks out all the time and the deadpan girl who may or may not be human but who is definitely crazy? Want another show with a similar dynamic, plus all sorts of nonsensical background characters and plot? Look into Haré+Guu or Arakawa.
Humanity has declined over time, leading to shortages in goods and the beginning of a bizarre relationship between humans and whimsical, sweets-loving fairies. Certain mediators help bridge the gap between the two species, as the magical, surprisingly-technological fairies are known to create various items the townsfolk need, albeit at oft-questionable quality levels. One such mediator, along with her faithful silent assistant, adorable fairy Nakata and frenemies such as yaoi-loving Y, will navigate her eventful daily life, whether it's investigating a strange factory or trying to escape the pages of a comic book.
Yukino had it all. Brilliant, athletic, popular and pretty, she was the perfect school girl with many friends and admirers. But then one fateful day she met her match: a handsome young man named Arima. Now, not only is he beating her at her own game, she's becoming more and more dismayed to learn that she's developing her first real feelings of romance. Can Yukino maintain her model student appearance, or will love ruin all her plans?
In Kare Kano there's a style (The screen showing trafic lights to say that the characters are walking home or showing something on screen for less than a second) that seems very similar to Studio Shaft's style. Also both shows are about first love. If you liked one you should watch the other.
Tsukimi is an otaku and jellyfish enthusiast whose only means of coping with the world is to reject it: she and her friends live in a house they declare a man-free zone, generally avoid 'stylish people', and spend their days blissfully bonding over geeky rituals. As misfortune would have it, their convenient existence is about to be turned on its head by the arrival of Kuranosuke, a seemingly beautiful young woman who is actually a beautiful young man. While he may be strange even by their standards, Kuranosuke embodies everything Tsukimi secretly dreams of being - a princess as ethereal as a floating jellyfish - and promises the kind of mind-boggling adventures only possible when geek meets chic!
I found both anime very similar just based on the random otaku-ness of the characters. Arakawa has less of a plot, and Kuragehime is decidedly more of a love story, but I think that if you liked the characters in one of these anime, you would certainly enjoy the other.