Anime with characters that have, overcome, or develop mobility issues during the course of the show. Some characters may walk on crutches, some are wheelchairbound, while still others may gradually lose muscle control and have to be hospitalized or...
From both in local TV and cable TV:
A Little Princess Sara
A Little Snow Fairy Sugar
Ah! My Goddess
Ai to Yuuki no Pig Girl Tonde Buurin (Super Pig)
Akazukin Chacha (Red Riding Hood Chacha)
The 20th century produced some great anime. Many shows we remember fondly from our own childhood, while others we never got the chance to experience back in the day. Here's a list of quality family-friendly series and animated movies from the 70's...
I remember watching all of these at some stage on French TV in the 1980's. Amazing what got past censors then eh? (Cat's Eyes, I'm looking at you)
I haven't rated these unless I have gone back and watched them again in their entirety recently...